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BRENDA support

Literature summary for 3.4.23.46 extracted from

  • van Bebber, F.; Hruscha, A.; Willem, M.; Schmid, B.; Haass, C.
    Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes (2013), J. Neurochem., 127, 471-481.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Danio rerio Q6NZT7
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Source Tissue

Source Tissue Comment Organism Textmining

General Information

General Information Comment Organism
physiological function homozygous bace1 mutants are hypomyelinated in the peripheral nervous system while the central nervous system is not affected. The number of mechanosensory neuromasts is elevated. Double homozygous Bace1/Bace2 fish do not enhance the single mutant phenotypes indicating non-redundant distinct physiological functions. Single homozygous bace1 mutants as well as double homozygous bace1 and bace2 mutants are viable and fertile Danio rerio