Application | Comment | Organism |
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medicine | BACE1 knock-out mice have markedly enhanced clearance of axonal and myelin debris from degenerated fibers, accelerated axonal regeneration, and earlier reinnervation of neuromuscular junctions, compared with littermate controls. data suggest BACE1 inhibition as a therapeutic approach to accelerate regeneration and recovery after peripheral nerve damage | Mus musculus |
Organism | UniProt | Comment | Textmining |
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Mus musculus | - |
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General Information | Comment | Organism |
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physiological function | BACE1 knock-out and wild-type nerves degenerate at a similar rate after axotomy and to a similar extent in the experimental neuropathies produced by administration of paclitaxel and acrylamide. BACE1 knock-out mice have markedly enhanced clearance of axonal and myelin debris from degenerated fibers, accelerated axonal regeneration, and earlier reinnervation of neuromuscular junctions, compared with littermate controls | Mus musculus |