Literature summary for 3.4.23.46 extracted from

Andreoli, F.; Doukara, A.L.; Mehdid, M.A.; Vanthuyne, N.; Roussel, C.; Dessolin, J.; Kraus, J.L.
Novel phenyl(thio)ureas bearing (thio)oxothiazoline group as potential BACE-1 inhibitors: synthesis and biological evaluation (2013), J. Enzyme Inhib. Med. Chem., 28, 153-162.

Inhibitors

Inhibitors	Comment	Organism	Structure
1,3-bis(3,5-bis(trifluoromethyl)phenyl)urea	100% inhibition at 100 nM, 15% inhibition at 10 nM	Homo sapiens
1-(3,5-bis(trifluoromethyl)-phenyl)-3-(3,5-dimethylphenyl)urea	80% inhibition at 100 nM	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	P56817	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)