Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.46 extracted from

  • Cho, J.K.; Ryu, Y.B.; Curtis-Long, M.J.; Kim, J.Y.; Kim, D.; Lee, S.; Lee, W.S.; Park, K.H.
    Inhibition and structural reliability of prenylated flavones from the stem bark of Morus lhou on beta-secretase (BACE-1) (2011), Bioorg. Med. Chem. Lett., 21, 2945-2948.
    View publication on PubMed
Search for more literature for 3.4.23.46

Inhibitors

Inhibitors Comment Organism Structure
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one i.e. norartocarpetin, prenylated flavone from the stem bark of Morus lhou, noncompetitive Homo sapiens
kuwanon prenylated flavone from the stem bark of Morus lhou, noncompetitive Homo sapiens
kuwanon A prenylated flavone from the stem bark of Morus lhou, noncompetitive Homo sapiens
morusin prenylated flavone from the stem bark of Morus lhou, noncompetitive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
rhodamine-EVNLDAEFK-Quencher FRET oligopeptide substrate Homo sapiens ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0034
-
 prenylated flavone from the stem bark of Morus lhou, pH not specified in the publication, temperature not specified in the publication Homo sapiens kuwanon
0.0053
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens kuwanon A
0.0594
-
 prenylated flavone from the stem bark of Morus lhou, pH not specified in the publication, temperature not specified in the publication Homo sapiens morusin
0.0606
-
 prenylated flavone from the stem bark of Morus lhou, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one