Literature summary for 3.4.23.46 extracted from

Xu, W.; Chen, G.; Zhu, W.; Zuo, Z.
Molecular docking and structure-activity relationship studies on benzothiazole based non-peptidic BACE-1 inhibitors (2010), Bioorg. Med. Chem. Lett., 20, 6203-6207.

Search for more literature for 3.4.23.46

Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking and structure-activity relationship studies. A pyrrolidinyl side group at the P3' and P4' positions of the inhibitors are favored for strong inhibition and a small aromatic group at the P4 position is also essential to the potency	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	a pyrrolidinyl side group at the P3' and P4' positions of the inhibitors are favored for strong inhibition and a small aromatic group at the P4 position is also essential to the potency	Homo sapiens
N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(6-[[4,6-di(piperidin-1-yl)-1,3,5-triazin-2-yl]amino]-1,3-benzothiazol-2-yl)sulfanyl]acetamide	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P56817	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00012	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(6-[[4,6-di(piperidin-1-yl)-1,3,5-triazin-2-yl]amino]-1,3-benzothiazol-2-yl)sulfanyl]acetamide

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)