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Literature summary for 3.4.23.46 extracted from

  • Marumoto, S.; Miyazawa, M.
    beta-Secretase inhibitory effects of furanocoumarins from the root of Angelica dahurica (2010), Phytother. Res., 24, 510-513.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(+)-byakangelicin
-
Homo sapiens
(+)-byakangelicol
-
Homo sapiens
(+)-oxypeucedanin
-
Homo sapiens
imperatorin strongest inhibition of BACE1 activity Homo sapiens
isoimperatorin
-
Homo sapiens
Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-(statine)-Val-Ala-Glu-Phe-OH
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
rhodamine-EVNLDAEFK-quencher + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
BACE1
-
Homo sapiens
beta-secretase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-(statine)-Val-Ala-Glu-Phe-OH
0.0918
-
in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens imperatorin
0.1049
-
in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens (+)-byakangelicol
0.2197
-
in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens (+)-byakangelicin
0.2442
-
in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens isoimperatorin
0.3592
-
in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens (+)-oxypeucedanin