Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-gallocatechin gallate | less potent inhibitor | Homo sapiens | |
Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-[statine(3S,4S)]-Val-Ala-Glu-Phe-OH | - |
Homo sapiens | |
N-((1S,2R)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(methanesulfonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide | beta-secretase inhibitor IV, potent inhibitor | Homo sapiens | |
OM99-2 | i.e. Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Ala-Glu-Phe-OH, potent inhibitor | Homo sapiens | |
pepstatin A | less potent inhibitor | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00191 | - |
M-2420 peptide | apparent value, free enzyme, pH and temperature not specified in the publication | Homo sapiens | |
0.00832 | - |
M-2420 peptide | apparent value, immobilized enzyme reactor enzyme, pH and temperature not specified in the publication | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Swedish mutation of amyloid precursor protein + H2O | Homo sapiens | - |
fragments of Swedish mutation of amyloid precursor protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein-FITC + H2O | - |
Homo sapiens | ? | - |
? | |
M-2420 peptide + H2O | cleavage occurs between Leu and Asp | Homo sapiens | MCA-Ser-Glu-Val-Asn-Leu + Asp-Ala-Glu-Phe-(N6-dinitrophenylacetyl)Lys-amide | - |
? | |
panvera peptide + H2O | - |
Homo sapiens | ? | - |
? | |
Swedish mutation of amyloid precursor protein + H2O | - |
Homo sapiens | fragments of Swedish mutation of amyloid precursor protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-amyloid precursor protein cleaving enzyme | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | - |
free enzyme, pH and temperature not specified in the publication | Homo sapiens | OM99-2 | |
0.00014 | - |
enzyme reactor-immobilized enzyme, pH and temperature not specified in the publication | Homo sapiens | Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-[statine(3S,4S)]-Val-Ala-Glu-Phe-OH | |
0.00014 | - |
free enzyme, pH and temperature not specified in the publication | Homo sapiens | Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-[statine(3S,4S)]-Val-Ala-Glu-Phe-OH | |
0.00046 | - |
enzyme reactor-immobilized enzyme, pH and temperature not specified in the publication | Homo sapiens | N-((1S,2R)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(methanesulfonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide | |
0.0007 | - |
enzyme reactor-immobilized enzyme, pH and temperature not specified in the publication | Homo sapiens | OM99-2 | |
0.00311 | - |
free enzyme, pH and temperature not specified in the publication | Homo sapiens | (-)-gallocatechin gallate | |
0.02119 | - |
free enzyme, pH and temperature not specified in the publication | Homo sapiens | pepstatin A | |
0.1275 | - |
enzyme reactor-immobilized enzyme, pH and temperature not specified in the publication | Homo sapiens | (-)-gallocatechin gallate | |
0.482 | - |
enzyme reactor-immobilized enzyme, pH and temperature not specified in the publication | Homo sapiens | pepstatin A |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.286 | - |
panvera peptide | free enzyme, pH and temperature not specified in the publication | Homo sapiens | |
3.298 | - |
casein-FITC | free enzyme, pH and temperature not specified in the publication | Homo sapiens | |
6.222 | - |
M-2420 peptide | free enzyme, pH and temperature not specified in the publication | Homo sapiens |