Application | Comment | Organism |
---|---|---|
medicine | samples from frontal cortex of both Alzheimer's disease-affected individuals and age-matched controls. BACE1 activity shows a significant positive correlation with the amount of extractable amyloid beta-peptide, and BACE1 protein and activity are significantly increased in cases of alzheimer's disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-((1S,2R)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(methanesulfonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide | beta-secretase inhibitor IV | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Homo sapiens | 5768 | - |
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Homo sapiens | BACE1 cleaves amyloid precursor protein at the beta-site | fragments of amyloid precursor protein | - |
? | |
amyloid precursor protein-DELTANL + H2O | Homo sapiens | the Swedish familial mutation in APP (DELTANL) enhances beta-secretase cleavage | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | high expression | Homo sapiens | - |
cerebral cortex | samples from frontal cortex of both Alzheimer's disease-affected individuals and age-matched controls. BACE1 activity shows a significant positive correlation with the amount of extractable amyloid beta-peptide, and BACE1 protein and activity are significantly increased in cases of alzheimer's disease | Homo sapiens | - |
neuron | - |
Homo sapiens | - |
pancreas | high expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | BACE1 cleaves amyloid precursor protein at the beta-site | Homo sapiens | fragments of amyloid precursor protein | - |
? | |
amyloid precursor protein-DELTANL + H2O | the Swedish familial mutation in APP (DELTANL) enhances beta-secretase cleavage | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000015 | - |
pH and temperature not specified in the publication | Homo sapiens | N-((1S,2R)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(methanesulfonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | BACE1 activity is substantially increased in the superior frontal gyrus in AlzheimerÂ’s disease cases | up |
General Information | Comment | Organism |
---|---|---|
physiological function | BACE1 is the principle beta-secretase responsible for the production of beta-amyloid in the brain | Homo sapiens |