Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-secretase inhibitor IV | complete inhibition at 0.001 mM | Homo sapiens | |
OM99-2 | complete inhibition at 0.0001 nM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Homo sapiens | - |
fragments of amyloid precursor protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | - |
Homo sapiens | fragments of amyloid precursor protein | - |
? | |
SEVKMDAEFRHDSGYEK-biotin + H2O | - |
Homo sapiens | ? | - |
? | |
SEVNLDAEFRHDSGYEK-biotin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
BACE1/beta-secretase | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000024 | - |
using SEVNLDAEFRHDSGYEK-biotin as substrate, in 50 mM sodium acetate, pH 4.5, containing 0.25 mg/ml bovine serum albumin, temperature not specified in the publication | Homo sapiens | OM99-2 | |
0.0000033 | - |
using SEVKMDAEFRHDSGYEK-biotin as substrate, in 50 mM sodium acetate, pH 4.5, containing 0.25 mg/ml bovine serum albumin, temperature not specified in the publication | Homo sapiens | OM99-2 | |
0.0000098 | - |
using SEVNLDAEFRHDSGYEK-biotin as substrate, in 50 mM sodium acetate, pH 4.5, containing 0.25 mg/ml bovine serum albumin, temperature not specified in the publication | Homo sapiens | beta-secretase inhibitor IV | |
0.0000124 | - |
using SEVKMDAEFRHDSGYEK-biotin as substrate, in 50 mM sodium acetate, pH 4.5, containing 0.25 mg/ml bovine serum albumin, temperature not specified in the publication | Homo sapiens | beta-secretase inhibitor IV |