Literature summary for 3.4.23.46 extracted from

Bloch, L.; Sineshchekova, O.; Reichenbach, D.; Reiss, K.; Saftig, P.; Kuro-o, M.; Kaether, C.
Klotho is a substrate for alpha-, beta- and gamma-secretase (2009), FEBS Lett., 583, 3221-3224.

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Application

Application	Comment	Organism
medicine	BACE1 is potential drug target for the treatment of Alzheimers disease and Notch-driven cancer types	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
N-((1S,2R)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(methanesulfonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide	beta-secretase inhibitor IV	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
amyloid precursor protein + H2O	Homo sapiens	-	fragments of amyloid precursor protein	-	?
Klotho protein + H2O	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid precursor protein + H2O	-	Homo sapiens	fragments of amyloid precursor protein	-	?
Klotho protein + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
BACE1	-	Homo sapiens
beta-APP cleaving enzyme 1	-	Homo sapiens
beta-secretase	-	Homo sapiens

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Release 2023.1 (January 2023)