Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid precursor protein + H2O | Homo sapiens | - |
fragments of beta-amyloid precursor protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid precursor protein + H2O | - |
Homo sapiens | fragments of beta-amyloid precursor protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE-1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
beta-site APP-cleaving enzyme 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | BACE1 is involved in regulating ectodomain shedding, maturation and trafficking of the amyloid precursor protein family of proteins. BACE1 expression regulates the levels and species of full-length amyloid precursor-like protein 1, amyloid precursor protein, and amyloid precursor-like protein 2, of their shed ectodomains, and of their membrane-bound C-terminal fragments | Homo sapiens |