Literature summary for 3.4.23.46 extracted from

Nie, J.; Luo, Y.; Huang, X.N.; Gong, Q.H.; Wu, Q.; Shi, J.S.
Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampus (2010), Eur. J. Pharmacol., 626, 213-218.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
amyloid precursor protein + H2O	Rattus norvegicus	-	fragments of amyloid precursor protein	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hippocampus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid precursor protein + H2O	-	Rattus norvegicus	fragments of amyloid precursor protein	-	?

Synonyms

Synonyms	Comment	Organism
BACE1	-	Rattus norvegicus
beta-secretase	-	Rattus norvegicus
beta-site amyloid precursor protein cleaving enzyme 1	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	administration of icariin (30, 60 and 120 mg/kg) significantly reduces the contents of Abeta1-40 and the mRNA levels of beta-secretase in the hippocampus	down
Rattus norvegicus	injection of 0.01 mg beta-amyloid peptide segment 25-35 induces expression of beta-secretase in rat hippocampus	up

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Release 2023.1 (January 2023)