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Literature summary for 3.4.23.46 extracted from

  • Miners, J.S.; van Helmond, Z.; Kehoe, P.G.; Love, S.
    Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme (2010), Brain Pathol., 20, 794-802.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens
-
 fragments of amyloid precursor protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-amido-4-methylcoumarin-SEVNLDAEFRK-(2,4-dinitrophenyl)-RR-NH2 + H2O
-
 Homo sapiens ?
-
 ?
amyloid precursor protein + H2O
-
 Homo sapiens fragments of amyloid precursor protein
-
 ?

Synonyms

Synonyms Comment Organism
BACE-1
-
 Homo sapiens
beta-secretase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens BACE-1 activity correlates inversely with total soluble and oligomeric Abeta1-42 down
Homo sapiens no correlation is observed between BACE-1 activity and NEP protein level additional information
Homo sapiens BACE-1 activity correlates closely with age in controls and is significantly higher in Alzheimer's disease. BACE-1 activity correlates with total insoluble Abeta up