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Literature summary for 3.4.23.46 extracted from

  • Hills, I.D.; Holloway, M.K.; de Leon, P.; Nomland, A.; Zhu, H.; Rajapakse, H.; Allison, T.J.; Munshi, S.K.; Colussi, D.; Pietrak, B.L.; Toolan, D.; Haugabook, S.J.; Graham, S.L.; Stachel, S.J.
    A conformational constraint improves a beta-secretase inhibitor but for an unexpected reason (2009), Bioorg. Med. Chem. Lett., 19, 4993-4995.
    View publication on PubMed
Search for more literature for 3.4.23.46

Inhibitors

Inhibitors Comment Organism Structure
4-[1-(4-methoxyphenyl)-2-[4-(trifluoromethyl)phenyl]ethyl]-1-methyl-1H-imidazol-2-amine
-
 Homo sapiens
4-[2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)ethyl]-1-methyl-1H-imidazol-2-amine
-
 Homo sapiens
4-[4-fluoro-5-methoxy-2-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-imidazol-2-amine highly active BACE-1 inhibitor Homo sapiens
4-[5-methoxy-2-(2-methoxy-5-nitrophenyl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-imidazol-2-amine
-
 Homo sapiens
4-[5-methoxy-2-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-imidazol-2-amine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-amyloid precursor protein + H2O Homo sapiens
-
 fragments of amyloid precursor protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein + H2O
-
 Homo sapiens fragments of amyloid precursor protein
-
 ?

Synonyms

Synonyms Comment Organism
BACE-1
-
 Homo sapiens
beta-amyloid cleaving enzyme
-
 Homo sapiens
beta-secretase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000063
-
 pH and temperature not specified in the publication Homo sapiens 4-[4-fluoro-5-methoxy-2-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-imidazol-2-amine
0.00035
-
 pH and temperature not specified in the publication Homo sapiens 4-[5-methoxy-2-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-imidazol-2-amine
0.00047
-
 pH and temperature not specified in the publication Homo sapiens 4-[2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)ethyl]-1-methyl-1H-imidazol-2-amine
0.0018
-
 pH and temperature not specified in the publication Homo sapiens 4-[1-(4-methoxyphenyl)-2-[4-(trifluoromethyl)phenyl]ethyl]-1-methyl-1H-imidazol-2-amine
0.0032
-
 pH and temperature not specified in the publication Homo sapiens 4-[5-methoxy-2-(2-methoxy-5-nitrophenyl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-imidazol-2-amine