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Literature summary for 3.4.23.46 extracted from

  • Hebert, S.S.; Horre, K.; Nicolai, L.; Papadopoulou, A.S.; Mandemakers, W.; Silahtaroglu, A.N.; Kauppinen, S.; Delacourte, A.; De Strooper, B.
    Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimers disease correlates with increased BACE1/beta-secretase expression (2008), Proc. Natl. Acad. Sci. USA, 105, 6415-6420.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in Alzheimer's disease patients displaying abnormally high BACE1 protein the microRNA miR-29a/b-1 cluster is significantly and Alzheimer's disease-dementia-specific decreased. There is a potential causal relationship between miR-29a/b-1 expression and amyloid beta generation in a cell culture model Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Homo sapiens
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 sporadic Alzheimer's disease patients
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Homo sapiens
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brain BACE1 expression is decreased in diseased brain Homo sapiens
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Synonyms

Synonyms Comment Organism
BACE1/beta-secretase
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 Homo sapiens