Literature summary for 3.4.23.46 extracted from

Wen, Y.; Yu, W.H.; Maloney, B.; Bailey, J.; Ma, J.; Marie, I.; Maurin, T.; Wang, L.; Figueroa, H.; Herman, M.; Krishnamurthy, P.; Liu, L.; Planel, E.; Lau, L.F.; Lahiri, D.K.; Duff, K.
Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing (2008), Neuron, 57, 680-690.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	overexpression of peptide p25 leads to increased levels of BACE1 mRNA and protein in vitro and in vivo	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cells and PC-12 cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
EMD 565788	specific BACE1 inhibitor	Mus musculus
additional information	CP-681301 treatment leads to significant reduction of BACE1 mRNA and protein	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H-RE(EDANS)EVNLDAEFK(dabcyl)R-OH + H2O	-	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
BACE1	-	Mus musculus
beta-secretase	-	Mus musculus

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Release 2023.1 (January 2023)