Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | caspase-3 inhibitor Z-DEVD-FMK reduces BACE1 mRNA and protein levels, and inhibits its protease activity, thereby decreasing the amount of amyloid precursor protein C99 and amyloid beta in ischemic brains. Caspase-3 inhibition attenuates ischemia-induced amyloid beta-formation by reducing BACE1 production and activity | Rattus norvegicus | |
Z-DEVD-FMK | caspase-3 inhibitor Z-DEVD-FMK reduces BACE1 mRNA and protein levels, and inhibits its protease activity, thereby decreasing the amount of amyloid precursor protein C99 and beta-amyloid in ischemic brains | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
corpus striatum | BACE1 is significantly and time-dependently increased in the ipsilateral striatum | Rattus norvegicus | - |
corpus striatum | changes in caspase-3, amyloid beta and BACE1 levels are detected in rat striatum on different days after middle cerebral artery occlusion using immunostaining. The positive labeled cells of activated caspase-3, amyloid beta, and BACE1 are significantly and time-dependently increased in the ipsilateral striatum | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid precursor protein APP + H2O | - |
Rattus norvegicus | beta-amyloid protein + beta-amyloid precursor protein pre-peptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Rattus norvegicus |
beta-secretase | - |
Rattus norvegicus |