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Literature summary for 3.4.23.46 extracted from

  • Zhang, Q.; Yang, G.; Li, W.; Fan, Z.; Sun, A.; Luo, J.; Ke, Z.J.
    Thiamine deficiency increases beta-secretase activity and accumulation of beta-amyloid peptides (2011), Neurobiol. Aging, 32, 42-53.
    View publication on PubMed
Search for more literature for 3.4.23.46

Activating Compound

Activating Compound Comment Organism Structure
additional information in cells overexpressing amyloid precursor protein, thiamine deficiency promotes maturation of beta-site amyloid precursor protein cleaving enzyme 1, BACE1 and increases beta-secretase activity which results in elevated levels of beta-amyloid as well as beta-secretase cleaved C-terminal fragment. An inhibitor of beta-secretase efficiently reduces thiamine deficiency-induced up-regulation of amyloid beta and beta-secretase cleaved fragment. Thiamine supplementation reverses the thiamine deficiency-induced alterations. Thiamine deficiency treatment causes a significant accumulation of reactive oxygen species. Antioxidants suppress reactive oxygen species production and maturation of BACE1, as well as thiamine deficiency-induced amyloid beta accumulation. Exogenous amyloid beta1-40 enhances thiamine deficiency-induced production of reactive oxygen species Homo sapiens
additional information thiamine deficiency causes amyloid beta accumulation in the brain, which is reversed by thiamine supplementation. Thiamine deficiency can promote beta-secretase activity, and the accumulation of amyloid beta subsequently exacerbates thiamine deficiency-induced oxidative stress Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens
-
 C-terminal fragment + soluble N-terminal fragment APPbeta
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
 Homo sapiens
-
SH-SY5Y cell in cells overexpressing amyloid precursor protein, thiamine deficiency promotes maturation of beta-site amyloid precursor protein cleaving enzyme 1, BACE1 and increases beta-secretase activity which results in elevated levels of beta-amyloid as well as beta-secretase cleaved C-terminal fragment. An inhibitor of beta-secretase efficiently reduces thiamine deficiency-induced up-regulation of amyloid beta and beta-secretase cleaved fragment Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
 Homo sapiens C-terminal fragment + soluble N-terminal fragment APPbeta
-
 ?

Synonyms

Synonyms Comment Organism
BACE1
-
 Homo sapiens
beta-secretase
-
 Homo sapiens
beta-site APP cleaving enzyme 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens thiamine deficiency promotes maturation of BACE1 and increases beta-secretase activity after 3 days up