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Literature summary for 3.4.23.46 extracted from

  • Liu, W.W.; Todd, S.; Coulson, D.T.; Irvine, G.B.; Passmore, A.P.; McGuinness, B.; McConville, M.; Craig, D.; Johnston, J.A.
    A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human platelets (2009), J. Neurochem., 108, 341-349.
    View publication on PubMed
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Application

Application Comment Organism
medicine membrane cholesterol significantly influences membrane beta-secretase activity in a biphasic manner, with positive correlations at higher membrane cholesterol levels, and negative correlations at lower membrane cholesterol levels. Platelets from individuals with Alzheimer's disease or mild cognitive impairment are significantly more likely to lie within the negative correlation zone than control platelets. Pharmacological inhibition of SH-SY5Y beta-secretase activity results in increased membrane cholesterol levels Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
blood platelet membrane cholesterol significantly influences membrane beta-secretase activity in a biphasic manner, with positive correlations at higher membrane cholesterol levels, and negative correlations at lower membrane cholesterol levels. Platelets from individuals with Alzheimer's disease or mild cognitive impairment are significantly more likely to lie within the negative correlation zone than control platelets Homo sapiens
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SH-SY5Y cell membrane cholesterol significantly influences membrane beta-secretase activity in a biphasic manner, with positive correlations at higher membrane cholesterol levels, and negative correlations at lower membrane cholesterol levels. Pharmacological inhibition of SH-SY5Y beta-secretase activity results in increased membrane cholesterol levels Homo sapiens
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