Literature summary for 3.4.23.46 extracted from

Yu, C.J.; Wang, W.Z.; Liu, W.
beta-Secretase inhibitor increases amyloid-beta precursor protein level in rat brain cortical primary neurons induced by okadaic acid (2008), Chin. Med. Sci., 121, 1439-1444.

Search for more literature for 3.4.23.46

Application

Application	Comment	Organism
pharmacology	inhibition of BACE1 may protect neurons from death induced by okadaic acid. Because of increased accumulation of amyloid beta precursor protein in neurons after okadaic acid treatment, more amyloid beta precursor protein turns to be cleaved by beta-secretase, producing neurotoxic beta-C-terminal fragment	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
BACEi-II	inhibition may protect neurons from death induced by okadaic acid	Rattus norvegicus
beta-secretase inhibitor-II	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
cerebral cortical neuron	-	Rattus norvegicus	-
neuron	primary culture of cortical neuron	Rattus norvegicus	-
primary culture	of cortical neuron	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid precursor protein + H2O	-	Rattus norvegicus	fragments of amyloid precursor protein	-	?

Synonyms

Synonyms	Comment	Organism
BACE1	-	Rattus norvegicus
beta-secretase	-	Rattus norvegicus

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Release 2023.1 (January 2023)