Application | Comment | Organism |
---|---|---|
medicine | roles of BACE1 in regulation postmenopausal memory effects analyzed | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P56818 | female ICR mice, ovariectomized or sham-operated, treated with or without daily restraint stress conditions for 6 h per day over 3 weeks | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | expression of BACE1 in CA1 and C3 regions analyzed under combination of chronic stress and ovariectomy | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
increased BACE1 activity determined in hippocampal CA1 and CA3 regions of mice tretated by combination of ovariectomy and chronic stress, condition shown to evoke an impairment of hippocampus-dependent memory, association between stressful life after menopause and Alzheimer disease-related molecules suggested, BACE1 discussed as the most sensitive molecule | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | influence of combination of ovariectomy and chronic stress on BACE1 activity analyzed | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Mus musculus |
beta-secretase | - |
Mus musculus |