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Literature summary for 3.4.23.46 extracted from

  • Hu, X.; Hicks, C.W.; He, W.; Wong, P.; Macklin, W.B.; Trapp, B.D.; Yan, R.
    BACE1 modulates myelination in the central and peripheral nervous system (2006), Nat. Neurosci., 9, 1520-1525.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information BACE1-null mice instrumental in validating roles of BACE1 in regulation of myelination Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P56818 BACE1-null and wild-type mice at the ages of 2 and 5 months
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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genetic deletion of BACE1 causes hypomyelination, elevated pain sensitivity and reduced grip strength shown in BACE1-null mice, neuregulin-1 expression increased and cleavage products and phosphorylated AKT protein kinase shown to be decreased in BACE1-null mice, neuregulin-1 cleavage by BACE1 shown, processed neuregulin-1 regulates myelination by means of phosphorylation of AKT protein kinase in myelin-forming cells Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information BACE1 function in regulation of myelination and myelin sheath thickness in the central and peripheral nerves determined, abolishment of BACE1 shown to be associated with altered neurological behaviors such as elevated pain sensitivity and reduced grip strength, altered neuregulin-AKT kinase signalling pathway in BACE1-null mice shown Mus musculus ?
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Synonyms

Synonyms Comment Organism
BACE1
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Mus musculus
beta-secretase
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Mus musculus