Protein Variants | Comment | Organism |
---|---|---|
additional information | BACE1 knockout mice instrumental in validating BACE1 as regulator of voltage-gated sodium channels and neuronal activity | Homo sapiens |
additional information | BACE1 knockout mice instrumental in validating BACE1 as regulator of voltage-gated sodium channels and neuronal activity | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | membrane excitability normalized by BACE1 inhibitor GL189 in Alzheimer disease patients reveals association between BACE1 and regulatory role on voltage-gated sodium channel by cleavage of beta2 subunit | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta2 subunit of voltage-gated sodium channel + H2O | Homo sapiens | - |
? | - |
? | |
beta2 subunit of voltage-gated sodium channel + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P56817 | - |
- |
Mus musculus | P56818 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | Alzheimer disease patients, endogenous processing of beta2 subunit of voltage-gated sodium channel found to be increased | Homo sapiens | - |
brain | cleavage products of BACE1 determined, sodium-current densities reduced in neuroblastoma cells and hippocampal cells of transgenic mice | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
beta2 subunit of voltage-gated sodium channel analyzed as substrate of BACE1, increase of mRNA and protein levels of pore-forming alpha subunit of sodium channel after cleavage observed, regulation of alpha subunit of voltage-gated sodium channel mediated through BACE1, association between BACE1 and cell-surface sodium current densities shown | Homo sapiens |
additional information | - |
beta2 subunit of voltage-gated sodium channel analyzed as substrate of BACE1, increase of mRNA and protein levels of pore-forming alpha subunit of sodium channel after cleavage observed, regulation of alpha subunit of voltage-gated sodium channel mediated through BACE1, association between BACE1 and cell-surface sodium current densities shown | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta2 subunit of voltage-gated sodium channel + H2O | - |
Homo sapiens | ? | - |
? | |
beta2 subunit of voltage-gated sodium channel + H2O | - |
Mus musculus | ? | - |
? | |
beta2 subunit of voltage-gated sodium channel + H2O | substrate cleavage investigated, cleavage products beta2-CTFbeta and beta2-ICD characterized, multiple roles in regulating neuronal function through regulating of neuronal BACE1 substrate proteins discussed | Homo sapiens | ? | - |
? | |
beta2 subunit of voltage-gated sodium channel + H2O | substrate cleavage investigated, cleavage products beta2-CTFbeta and beta2-ICD characterized, multiple roles in regulating neuronal function through regulating of neuronal BACE1 substrate proteins discussed | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
BACE1 | - |
Mus musculus |
beta-secretase | - |
Homo sapiens |
beta-secretase | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
cleavage of beta2 subunit of voltage-gated sodium channel by BACE1 observed at pH 4.5 but not at pH 7 | Homo sapiens |
4.5 | - |
cleavage of beta2 subunit of voltage-gated sodium channel by BACE1 observed at pH 4.5 but not at pH 7 | Mus musculus |