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Literature summary for 3.4.23.46 extracted from

  • Tamagno, E.; Guglielmotto, M.; Aragno, M.; Borghi, R.; Autelli, R.; Giliberto, L.; Muraca, G.; Danni, O.; Zhu, X.; Smith, M.A.; Perry, G.; Jo, D.G.; Mattson, M.P.; Tabaton, M.
    Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein (2008), J. Neurochem., 104, 683-695.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
4-hydroxynonenal induction of BACE1 expression under oxidative stress determined Mus musculus
H2O2 induction of BACE1 expression under oxidative stress determined Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P56818 BalbC mice
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Mus musculus BalbC P56818 BalbC mice
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Source Tissue

Source Tissue Comment Organism Textmining
brain cytosolic and nuclear extracts of mouse brain tissues Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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oxidative stress measured in cytosolic fractions, antibodies and immunoblot analysis performed, RNA interference and Luciferase reporter gene assay applied, stimulation of BACE1 expression by oxidative stress determined, mechanism shown to require gamma-secretase activity involving the c-jun N-terminal kinase (JNK)/c-jun pathway, inceased BACE1 levels identified in normal cells, but not in cells lacking presenilins or amyloid precursor protein, correlation with activation of JNK and c-jun determined Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information BACE1 expression shown to be stimulated by oxidative stress, mechanism of transcriptional induction of BACE1 by oxidative stress discussed as a contribution to production of pathological levels of amyloid beta protein in Alzheimer disease Mus musculus ?
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?
additional information BACE1 expression shown to be stimulated by oxidative stress, mechanism of transcriptional induction of BACE1 by oxidative stress discussed as a contribution to production of pathological levels of amyloid beta protein in Alzheimer disease Mus musculus BalbC ?
-
?

Synonyms

Synonyms Comment Organism
BACE1
-
Mus musculus
beta-secretase
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Mus musculus