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Literature summary for 3.4.23.46 extracted from
- BACE1 structure and function in health and Alzheimers disease (2008), Curr. Alzheimer Res., 5, 100-120.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | overview about therapeutic strategies by focusing on BACE1 for treatment of Alzheimer disease | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | overview about BACE1 knockout (BACE1-/-) mice instrumental in validating BACE1 as the authentic beta-secretase in vivo, behavioral and physiological alterations of BACE1 knockout mice summarized | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P56817 | - |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
basic biology of BACE1 focusing on the regulation, structure and function reviewed, overview about dysregulation of BACE1 in Alzheimer disease, behavioral and physiological alterations of BACE1 knockout mice described, putative function of BACE1 during normal conditions summarized, relationship between key risk factors for Alzheimer disease and the pathogenic alterations in BACE1 observed in the diseased state discussed | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | substrate specificity of BACE1 summarized, identification of different substrates suggests several roles in brain, association of complete abolishment of BACE1 with specific behavioral and physiological alterations discussed, relationships between key risk factors for Alzheimer disease and pathogenic alterations of BACE1 summarized | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE1 | - |
Homo sapiens |
| beta-secretase | - |
Homo sapiens |
| beta-site APP cleaving enzyme 1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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