Application | Comment | Organism |
---|---|---|
medicine | screening of natural products for anti-dementia agents | Perilla frutescens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
luteolin | isolated from methanolic extracts of Perilla frutescens | Perilla frutescens | |
rosmarinic acid | isolated from methanolic extracts of Perilla frutescens | Perilla frutescens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Perilla frutescens | - |
var. acuta | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | methanolic extracts of Perilla frutescens | Perilla frutescens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
beta-secretase (BACE1) inhibitors isolated from the methanolic extract of Perilla frutescens characterized, specificity against beta-secretase BACE1 higher than for other enzymes such as alpha-secretase (TACE), acetylcholine esterase (AchE), chymotrypsin, and elastase | Perilla frutescens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | inhibitors of beta-secretase BACE1 identified and tested | Perilla frutescens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Perilla frutescens |
beta-secretase | - |
Perilla frutescens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.039 | - |
rosmarinic acid | - |
Perilla frutescens | |
0.062 | - |
luteolin | - |
Perilla frutescens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | - |
non-competitive inhibition | Perilla frutescens | luteolin | |
0.0021 | - |
non-competitive inhibition | Perilla frutescens | rosmarinic acid |