KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | ratio kcat/Km for substrates SEVKMDAEFR and EEISEVKMDAEFRG is 53.3 per M and s and 95 per M and s, respectively | Homo sapiens | |
1.71 | - |
EEISEVNLDAEFRG | in 44 mM acetic acid/6 mM Na-acetate pH 3.8, 10 mM beta-mercaptoethanol, at 37°C | Homo sapiens | |
1.71 | - |
EEISEVNLDAEFRG | pH 3.8, 37°C | Homo sapiens | |
4.07 | - |
SEVNLDAEFR | in 44 mM acetic acid/6 mM Na-acetate pH 3.8, 10 mM beta-mercaptoethanol, at 37°C | Homo sapiens | |
4.07 | - |
SEVNLDAEFR | pH 3.8, 37°C | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | both BACE1 and human cathepsin D show poor activity towards the wild-type amyloid beta-site sequence | Homo sapiens | - |
cerebral cortex | - |
Homo sapiens | - |
hippocampus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid precursor protein APP + H2O | - |
Homo sapiens | beta-amyloid protein + beta-amyloid precursor protein pre-peptide | - |
? | |
EEISEVKMDAEFRG + H2O | - |
Homo sapiens | EEISEVKM + DAEFRG | - |
? | |
EEISEVNLDAEFRG + H2O | - |
Homo sapiens | EEISEVNL + DAEFRG | - |
? | |
SEVKMDAEFR + H2O | - |
Homo sapiens | SEVKM + DAEFR | - |
? | |
SEVNLDAEFR + H2O | - |
Homo sapiens | SEVNL + DAEFR | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
10.7 | - |
SEVNLDAEFR | in 44 mM acetic acid/6 mM Na-acetate pH 3.8, 10 mM beta-mercaptoethanol, at 37°C | Homo sapiens | |
10.7 | - |
SEVNLDAEFR | pH 3.8, 37°C | Homo sapiens | |
17.6 | - |
EEISEVNLDAEFRG | in 44 mM acetic acid/6 mM Na-acetate pH 3.8, 10 mM beta-mercaptoethanol, at 37°C | Homo sapiens | |
17.6 | - |
EEISEVNLDAEFRG | pH 3.8, 37°C | Homo sapiens |