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Literature summary for 3.4.23.46 extracted from

  • Turner, R.T.; Koelsch, G.; Hong, L.; Castenheira, P.; Ghosh, A.; Tang, J.
    Subsite specificity of memapsin 2 (b-secretase): implications for inhibitor design (2001), Biochemistry, 40, 10001-10006.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens broad endopeptidase specificity, cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
Homo sapiens ?
-
?
additional information broad endopeptidase specificity, cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein Homo sapiens ?
-
?
additional information requirements for substrate subsites Homo sapiens ?
-
?
Swedish variant of amyloid precursor protein + H2O
-
Homo sapiens ?
-
?