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Literature summary for 3.4.23.16 extracted from

  • Adachi, M.; Ohhara, T.; Kurihara, K.; Tamada, T.; Honjo, E.; Okazaki, N.; Arai, S.; Shoyama, Y.; Kimura, K.; Matsumura, H.; Sugiyama, S.; Adachi, H.; Takano, K.; Mori, Y.; Hidaka, K.; Kimura, T.; Hayashi, Y.; Kiso, Y.; Kuroki, R.
    Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography (2009), Proc. Natl. Acad. Sci. USA, 106, 4641-4646.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
Q7K/L33I/L63I/C67A/C95A mutant protein expressed in Escherichia coli Human immunodeficiency virus 1

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal of HIV1 protease complexed with KNI-272 Human immunodeficiency virus 1

Protein Variants

Protein Variants Comment Organism
Q7K/L33I/L63I/C67A/C95A mutations prevent autoproteolysis and cysteine thiol oxidation Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
KNI-272 transition-state analog Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Purification (Commentary)

Purification (Comment) Organism
cation exchange chromatography, reversed-phase chromatography Human immunodeficiency virus 1

Renatured (Commentary)

Renatured (Comment) Organism
-
 Human immunodeficiency virus 1

Subunits

Subunits Comment Organism
homodimer
-
 Human immunodeficiency virus 1

Synonyms

Synonyms Comment Organism
HIV-1 protease
-
 Human immunodeficiency virus 1