Crystallization (Comment) | Organism |
---|---|
purified recombinant mutant F53L, hanging drop vapour diffusion method, X-ray diffraction and analysis at 1.35 A resolution | Human immunodeficiency virus 1 |
Protein Variants | Comment | Organism |
---|---|---|
F53L | site-directed mutagenesis in the flexible flap region, the mutation leads to 15% reduced catalytic efficiency, 20fold higher resistance against indinavir, and reduced dimer stability | Human immunodeficiency virus 1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
indinavir | drug used in AIDS therapy, mechanism of drug resistance, overview | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
i.e. HIV-1 | - |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Human immunodeficiency virus 1 |
Synonyms | Comment | Organism |
---|---|---|
HIV-1 PR | - |
Human immunodeficiency virus 1 |
HIV-1 protease | - |
Human immunodeficiency virus 1 |