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Literature summary for 3.4.23.16 extracted from

  • Szeltner, Z.; Polgar, L.
    Rate-determining steps in HIV-1 protease catalysis. The hydrolysis of the most specific substrate (1996), J. Biol. Chem., 271, 32180-32184.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00069
-
2-aminobenzoyl-TI-Nle-Phe(NO2)-ER pH 5.2, 2.0 M NaCl Human immunodeficiency virus 1
0.00084
-
2-aminobenzoyl-TI-Nle-Phe(NO2)-ER pH 4.5, 0.1 M NaCl Human immunodeficiency virus 1
0.00598
-
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR pH 5.0, 2.0 M NaCl Human immunodeficiency virus 1
0.00873
-
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR pH 4.9, 1.0 M NaCl Human immunodeficiency virus 1
0.0152
-
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR pH 4.u, 0.1 M NaCl Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-TI-Nle-Phe(NO2)-ER + H2O
-
Human immunodeficiency virus 1 2-aminobenzoyl-Thr-Ile-Nle + Phe(NO2)-Glu-Arg
-
?
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR + H2O
-
Human immunodeficiency virus 1 2-aminobenzoyl-Thr-Ile-Nle + Phe(NO2)-Gln-Arg
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.14
-
2-aminobenzoyl-TI-Nle-Phe(NO2)-ER pH 5.2, 2.0 M NaCl Human immunodeficiency virus 1
5.46
-
2-aminobenzoyl-TI-Nle-Phe(NO2)-ER pH 4.5, 0.1 M NaCl Human immunodeficiency virus 1
5.8
-
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR pH 4.8, 0.1 M NaCl Human immunodeficiency virus 1
9.25
-
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR pH 4.9, 1.0 M NaCl Human immunodeficiency virus 1
19.5
-
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR pH 5.0, 2.0 M NaCl Human immunodeficiency virus 1