Crystallization (Comment) | Organism |
---|---|
the structure of the HIV-1 protease in complex with A79285, a pseudo-C2 symmetric inhibitor, which contains a central difluoroketone motif determined with X-ray diffraction data extending to 1.7 A resolution. Crystals are grown at room temperature by hanging drop method with 37% w/v ammonium sulfate, 63 mM citrate and 126 mM sodium phosphate, pH 6.2 | Human immunodeficiency virus 1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
A79285 | a pseudo-C2 symmetric inhibitor, which contains a central difluoroketone motif | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
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Human immunodeficiency virus 1 | - |
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Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro | proteolysis mechanism whereby only one active site Asp is initially protonated. The steps of this mechanism are: asymmetric binding of the substrate, hydration of the peptidic carbonyl by an active site water, proton translocation between the active site Asp residue simultaneously with carbonyl hydration | Human immunodeficiency virus 1 |