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Literature summary for 3.4.23.16 extracted from
- The structural stability of the HIV-1 protease (1998), J. Mol. Biol., 283, 475-488.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Human immunodeficiency virus 1 |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
at pH 3.4 and a protease concentration of 0.05 mM (monomer) the midpoint of the heat denaturation transition is 59.5°C | Human immunodeficiency virus 1 |
| 62 | - |
at pH 3.7 the midpoint of the heat denaturation transition is 62°C | Human immunodeficiency virus 1 |
| 66 | - |
at pH 4 the midpoint of the heat denaturation transition is 62°C | Human immunodeficiency virus 1 |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 3.4 | - |
the Gibbs energy of stabilization is close to 10 kcal/mol at 25°C | Human immunodeficiency virus 1 |
| 5 | - |
the Gibbs energy of stabilization is 14.5 kcal/mol at 25°C | Human immunodeficiency virus 1 |
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