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Literature summary for 3.4.23.16 extracted from

  • Blundell, T.L.; Lapatto, R.; Wilderspin, A.F.; Hemmings, A.M.; Hobart, P.M.; Danley, D.E.; Whittle, P.J.
    The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS (1990), Trends Biochem. Sci., 15, 425-430.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
cloned and expressed in bacterial cells Human immunodeficiency virus 1

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
Ac-TI-Nle-(CH2-NH)-Nle-QR-amide
-
 Human immunodeficiency virus 1
renin inhibitors
-
 Human immunodeficiency virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Human immunodeficiency virus 1 the enzyme plays an essential role in the late-stage maturation step of the virus replication cycle. HIV-1 proteinase autocatalyzes its own cleavage from the Pr165 polyprotein precursor and then cleaves both polyproteins at other specific sites to produce mature proteins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme plays an essential role in the late-stage maturation step of the virus replication cycle. HIV-1 proteinase autocatalyzes its own cleavage from the Pr165 polyprotein precursor and then cleaves both polyproteins at other specific sites to produce mature proteins Human immunodeficiency virus 1 ?
-
 ?