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Literature summary for 3.4.23.15 extracted from

  • Kher, V.
    Renin inhibition - benefit beyond hypertension control (2009), J. Assoc. Physicians India, 57, 518-20, 525.
    View publication on PubMed

Application

Application Comment Organism
medicine renin inhibition is the preferred pharmacologic approach to blockade of the renin-angiotensin system. Renin inhibition offers substantial promise for cardioprotection and renoprotection Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
aliskiren
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensinogen + H2O Homo sapiens renin is a highly specific enzyme for angiotensinogen angiotensin I + angiotensinogen propeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensinogen + H2O renin is a highly specific enzyme for angiotensinogen Homo sapiens angiotensin I + angiotensinogen propeptide
-
?

General Information

General Information Comment Organism
physiological function renin is a key regulator of the renin-angiotensin system which is important for blood pressure and electrolyte regulation. High renin angiotensin system activity results in over-activation of the angiotensin AT1-receptor by its substrate, angiotensin II, leading to increases in blood pressure and direct growth-promoting effects on tissues that result in end-organ damage Homo sapiens