Application | Comment | Organism |
---|---|---|
medicine | renin inhibition is the preferred pharmacologic approach to blockade of the renin-angiotensin system. Renin inhibition offers substantial promise for cardioprotection and renoprotection | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aliskiren | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | Homo sapiens | renin is a highly specific enzyme for angiotensinogen | angiotensin I + angiotensinogen propeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | renin is a highly specific enzyme for angiotensinogen | Homo sapiens | angiotensin I + angiotensinogen propeptide | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | renin is a key regulator of the renin-angiotensin system which is important for blood pressure and electrolyte regulation. High renin angiotensin system activity results in over-activation of the angiotensin AT1-receptor by its substrate, angiotensin II, leading to increases in blood pressure and direct growth-promoting effects on tissues that result in end-organ damage | Homo sapiens |