Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aliskiren | renin inhibition is more than 99% at 5 h after the 300 and 600 mg aliskiren doses | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | Homo sapiens | - |
angiotensin I + angiotensinogen propeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | - |
Homo sapiens | angiotensin I + angiotensinogen propeptide | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000006 | - |
pH and temperature not specified in the publication | Homo sapiens | aliskiren |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | renin inhibitors like aliskiren increase the plasma concentration of renin because they attenuate the negative feedback effect of angiotensin II on renin release | up |