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Literature summary for 3.4.23.15 extracted from

  • Puig, J.G.; Schunkert, H.; Taylor, A.A.; Boye, S.; Jin, J.; Keefe, D.L.
    Evaluation of the dose--response relationship of aliskiren, a direct renin inhibitor, in an 8-week, multicenter, randomized, double-blind, parallel-group, placebo-controlled study in adult patients with stage 1 or 2 essential hypertension (2009), Clin. Ther., 31, 2839-2850.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
aliskiren orally effective, nonpeptide, low-molecular-weight, direct renin inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensinogen + H2O Homo sapiens
-
angiotensin I + angiotensinogen propeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-
kidney
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensinogen + H2O
-
Homo sapiens angiotensin I + angiotensinogen propeptide
-
?

Expression

Organism Comment Expression
Homo sapiens angiotensin II inhibits the release of renin from the kidney down
Homo sapiens diuretics increase plasma renin concentration and plasma renin activity, as volume depletion stimulates the release of renin from the kidney up