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Literature summary for 3.4.23.15 extracted from
- Direct renin inhibitors as antihypertensive agents (2010), Am. J. Ther., 17, 237-254.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| A 62198 | - |
Homo sapiens | |
| A 65317 | - |
Homo sapiens | |
| A 74273 | - |
Homo sapiens | |
| aliskiren | SPP-100, formerly CGP-60539 | Homo sapiens |  |
| BILA 2157 BS | - |
Homo sapiens | |
| BW 633C | - |
Homo sapiens | |
| BW-175 | - |
Homo sapiens | |
| CGP 29287 | - |
Homo sapiens | |
| CGP 38560A | - |
Homo sapiens | |
| CGP 44099 | - |
Homo sapiens | |
| CGP 60536 | - |
Homo sapiens | |
| CGP-29,287 | - |
Homo sapiens | |
| CGP-44099A | - |
Homo sapiens | |
| CI 992 | - |
Homo sapiens | |
| CI-992 | - |
Homo sapiens | |
| ciprokiren | Ro 44-9375 | Homo sapiens | |
| CP 71362 | - |
Homo sapiens | |
| CP 81282 | - |
Homo sapiens | |
| CP-72,647 | - |
Homo sapiens | |
| CP-80,794 | - |
Homo sapiens | |
| CP-81,198 | - |
Homo sapiens | |
| CP-81,282 | - |
Homo sapiens | |
| cyclothiazomycin | - |
Homo sapiens | |
| ditekren | U 71038 | Homo sapiens | |
| EMD 51921 | - |
Homo sapiens | |
| EMD 52297 | - |
Homo sapiens | |
| EMD 56133 | - |
Homo sapiens | |
| EMD 58265 | - |
Homo sapiens | |
| enalkiren | A 64662 | Homo sapiens | |
| ES 1005 | - |
Homo sapiens | |
| ES 6864 | - |
Homo sapiens | |
| ES-8891 | - |
Homo sapiens | |
| FK906 | - |
Homo sapiens | |
| GR 70982 | - |
Homo sapiens | |
| H-141 | - |
Homo sapiens | |
| H-142 | - |
Homo sapiens | |
| H-142-08 | - |
Homo sapiens | |
| H-189 | - |
Homo sapiens | |
| H-261 | - |
Homo sapiens | |
| H-77 | - |
Homo sapiens | |
| H-77-77 | - |
Homo sapiens | |
| KR1-1314 | - |
Homo sapiens | |
| KRI 1177 | - |
Homo sapiens | |
| N-acetyl-D-glucosamine-2-epimerase | - |
Homo sapiens | |
| PD 132002 | - |
Homo sapiens | |
| PD 133,450 | - |
Homo sapiens | |
| PD-129,541 | - |
Homo sapiens | |
| pepstatin A | SR 42128 | Homo sapiens | |
| R-PEP-27 | - |
Homo sapiens | |
| remikiren | RO 42-5892 | Homo sapiens | |
| renin inhibitory peptide | - |
Homo sapiens | |
| Ro 42-5892 | - |
Homo sapiens | |
| S-2864 | - |
Homo sapiens | |
| SC 46944 | - |
Homo sapiens | |
| SC 56525 | - |
Homo sapiens | |
| SQ 32970 | - |
Homo sapiens | |
| SQ 33800 | - |
Homo sapiens | |
| SR 43845 | - |
Homo sapiens | |
| terlakiren | CP 80794 | Homo sapiens | |
| YM-21095 | - |
Homo sapiens | |
| YM-26365 | - |
Homo sapiens | |
| zankiren | A 72517 | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | Homo sapiens | - |
angiotensin I + angiotensinogen propeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | - |
Homo sapiens | angiotensin I + angiotensinogen propeptide | - |
? | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000001 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | SR 43845 | |
| 0.0000001 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | PD 133,450 | |
| 0.0000003 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | CGP-44099A | |
| 0.00000035 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | SQ 33800 | |
| 0.0000004 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | ditekren | |
| 0.00000047 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | YM-21095 | |
| 0.0000005 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | Ro 42-5892 | |
| 0.00000058 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | CI-992 | |
| 0.0000006 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | aliskiren | |
| 0.0000006 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | FK906 | |
| 0.0000006 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | KR1-1314 | |
| 0.0000007 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | ES-8891 | |
| 0.000001 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | H-77 | |
| 0.000001 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | CGP-29,287 | |
| 0.0000011 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | terlakiren | |
| 0.0000029 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | YM-26365 | |
| 0.0000033 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | BW-175 | |
| 0.000005 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | CP-72,647 | |
| 0.000005 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | CP-81,282 | |
| 0.0000069 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | GR 70982 | |
| 0.0000073 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | ES 6864 | |
| 0.00001 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | CP-81,198 | |
| 0.00001 | - |
temperature not specified in the publication, at pH 7.4 | Homo sapiens | H-141 |
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