Literature summary for 3.4.23.15 extracted from

Sultana, A.; Nabi, A.H.; Biswas, K.B.; Takemoto, M.; Suzuki, F.
A peptide YY inhibits the human renin activity in a pH dependent manner (2009), Front. Biosci., 14, 3286-3291.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
modeling of stereo structure of the complex of human renin with dipeptide YY. The loss of inhibitory activiy at basic pH values may be due to a local shift of YY from the center of the renin cleft into the N-domain side	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
YY	dipeptide derived from royal jelly proteins. YY inhibits the renin activity only at acidic pH values below 8.0	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	YY	Ki value is estimated 4.6 micromol per l at pH 6.0	Homo sapiens

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Release 2023.1 (January 2023)