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BRENDA support

Literature summary for 3.4.23.15 extracted from

  • Fisher, N.D.; Jan Danser, A.H.; Nussberger, J.; Dole, W.P.; Hollenberg, N.K.
    Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans (2008), Circulation, 117, 3199-3205.
    View publication on PubMed

Application

Application Comment Organism
pharmacology renal vasodilation in healthy people with renin inhibitor aliskiren exceeds responses seen with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. The effects are longer lasting and are associated with significant natriuresis. Aliskiren may provide more complete and more effective blockade of the renin-angiotensin system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
aliskiren renal vasodilation in healthy people with aliskiren exceeds responses seen with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. The effects are longer lasting and are associated with significant natriuresis. Aliskiren may provide more complete and more effective blockade of the renin-angiotensin system Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining