Literature summary for 3.4.23.15 extracted from

Cobankara, V.; Oztuerk, M.A.; Kiraz, S.; Ertenli, I.; Haznedaroglu, I.C.; Pay, S.; Calgueneri, M.
Renin and angiotensin-converting enzyme (ACE) as active components of the local synovial renin-angiotensin system in rheumatoid arthritis (2005), Rheumatol. Int., 25, 285-291.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	serum and synovial fluid	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensinogen + H2O	Homo sapiens	renin is an active component of the local synovial renin-angiotensin system in rheumatoid arthritis, renin-angiotensin system in synovial fluid, overview	angiotensin I + angiotensinogen propeptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the inactive prorenin needs to be proteolytically activated to the mature active renin	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Homo sapiens	-
synovial fluid	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	renin content and activity in serum and synovial fluid from healthy persons, and from patients with osteoarthritis or rheumatism, overview	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensinogen + H2O	-	Homo sapiens	angiotensin I + angiotensinogen propeptide	-	?
angiotensinogen + H2O	renin is an active component of the local synovial renin-angiotensin system in rheumatoid arthritis, renin-angiotensin system in synovial fluid, overview	Homo sapiens	angiotensin I + angiotensinogen propeptide	-	?

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Release 2023.1 (January 2023)