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Literature summary for 3.4.23.15 extracted from
- Kinetics of renin inhibition by sodium houttuyfonate analogs (2006), Biosci. Biotechnol. Biochem., 70, 2275-2280.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| decanoyl acetal sodium sulfite | IC50: 0.273 mM | Homo sapiens |  |
| dodecanoyl acetal sodium sulfite | IC50: 0.195 mM | Homo sapiens | |
| hexanoyl acetal sodium sulfite | - |
Homo sapiens | |
| houttuynin | from the volatile oil of Houttuynia cordata | Homo sapiens | |
| octanoyl acetal sodium sulfite | - |
Homo sapiens | |
| tetradecanoyl acetal sodium sulfite | complex formation with the enzyme, mixed inhibition type, IC50: 0.044 mM | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0064 | - |
Arg-Glu(5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(4-(4-dimethylaminophenylazo)-benzoic acid)-Arg | pH 8.0, 37°C | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | from recombinant expression | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Arg-Glu(5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(4-(4-dimethylaminophenylazo)-benzoic acid)-Arg + H2O | commercial renin peptide substrate 1 | Homo sapiens | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics | Homo sapiens | |
| 0.045 | - |
tetradecanoyl acetal sodium sulfite | pH 8.0, 37°C | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.044 | - |
complex formation with the enzyme, mixed inhibition type, IC50: 0.044 mM | Homo sapiens | tetradecanoyl acetal sodium sulfite | |
| 0.195 | - |
IC50: 0.195 mM | Homo sapiens | dodecanoyl acetal sodium sulfite | |
| 0.273 | - |
IC50: 0.273 mM | Homo sapiens | decanoyl acetal sodium sulfite | |
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