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Literature summary for 3.4.23.15 extracted from
- High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells (2004), Am. J. Physiol. Renal Physiol., 286, F1039-F1045.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | high glucose concentration stimulates intracellular renin activity and angiotensin II generation in mesangial cells | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| intracellular | - |
Rattus norvegicus | 5622 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | Rattus norvegicus | high glucose concentration stimulates intracellular renin activity and angiotensin II generation in mesangial cells, mechanism, the renin-angiotensin system is involved in diabetic nephropathy, overview | angiotensin I + angiotensinogen propeptide | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | the inactive prorenin needs to be proteolytically activated to the mature active renin, activation in vitro by trypsin at 37°C | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mesangial cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | - |
Rattus norvegicus | angiotensin I + angiotensinogen propeptide | - |
? | |
| angiotensinogen + H2O | high glucose concentration stimulates intracellular renin activity and angiotensin II generation in mesangial cells, mechanism, the renin-angiotensin system is involved in diabetic nephropathy, overview | Rattus norvegicus | angiotensin I + angiotensinogen propeptide | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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