Literature summary for 3.4.22.B71 extracted from

Koo, Y.D.; Lee, J.S.; Lee, S.A.; Quaresma, P.G.F.; Bhat, R.; Haynes, W.G.; Park, Y.J.; Kim, Y.B.; Chung, S.S.; Park, K.S.
SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle (2019), Metab. Clin. Exp., 95, 27-35 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q91ZX6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C2C12 cell	-	Mus musculus	-

Expression

Organism	Comment	Expression
Mus musculus	leptin treatment of C2C12 myotubes causes STAT3 to bind to the Senp2 promoter, inducing SENP2 expression	up

General Information

General Information	Comment	Organism
physiological function	leptin treatment of C2C12 myotubes causes signal transducer and activator of transcription STAT3 to bind to the Senp2 promoter, inducing its expression. When Senp2 is knocked down in myotubes, leptin-induced expression of fatty acid oxidation-associated enzymes and prolonged increase of fatty acid oxidation are suppressed, but rapid increase of fatty acid oxidation is unaffected. Leptin-induced expression of fatty acid oxidation-associated enzymes is not observed in muscle tissue of SENP2 knockout mice	Mus musculus

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Release 2023.1 (January 2023)