Literature summary for 3.4.22.56 extracted from

Smart, A.D.; Pache, R.A.; Thomsen, N.D.; Kortemme, T.; Davis, G.W.; Wells, J.A.
Engineering a light-activated caspase-3 for precise ablation of neurons in vivo (2017), Proc. Natl. Acad. Sci. USA, 114, E8174-E8183 .

Search for more literature for 3.4.22.56

Application

Application	Comment	Organism
medicine	light-activated caspase-3 can be used for precise ablation of neurons in vivo	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
engineering of a light-activated human caspase-3 (Caspase-LOV) by exploiting its natural spring-loaded activation mechanism through rational insertion of the light-sensitive LOV2 domain that expands upon illumination. Using the tissue-specific expression system (UAS)-GAL4, Caspase-LOV is specifically expressed in three neuronal cell types: retinal, sensory, and motor neuron of Drosophila	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	engineering of a light-activated human caspase-3 (Caspase-LOV) by exploiting its natural spring-loaded activation mechanism through rational insertion of the light-sensitive LOV2 domain that expands upon illumination	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P20807	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)