Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | caspase-3 is one of the key executioners of apoptosis and responsible for the partial or total proteolytic cleavage of many proteins. Senescence-accelerated prone mice 8 and senescence-accelerated resistant mice 1 show a drop in age-related proteolytic activity of caspase-3, but the caspase-independent cell death, owing to high p53 and apoptosis-inducing factor levels, might be an alternative pathway of cell death in the aged brain | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | senescence-accelerated prone mice 8 and senescence-accelerated resistant mice 1 show a drop in age-related proteolytic activity of caspase-3, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-spectrin + H2O | - |
Mus musculus | ? | production of a 120 kDa fragment | ? | |
additional information | caspase-3 is one of the key executioners of apoptosis and responsible for the partial or total proteolytic cleavage of many proteins. Senescence-accelerated prone mice 8 and senescence-accelerated resistant mice 1 show a drop in age-related proteolytic activity of caspase-3, but the caspase-independent cell death, owing to high p53 and apoptosis-inducing factor levels, might be an alternative pathway of cell death in the aged brain | Mus musculus | ? | - |
? |