Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | staurosporine induces the enzyme | Cricetulus griseus |
Application | Comment | Organism |
---|---|---|
molecular biology | engineering of CHO cells for more robust cell lines includes reduction of apoptotic capase-3, overview | Cricetulus griseus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | engineering of CHO cells for more robust cell lines includes reduction of apoptotic capase-3, activities in different mutant cell lines, overview. The cells exhibit a reduction in caspase 3 activity of at least 60% and a 170% enhancement in mitochondrial membrane potential compared to controls when treated with staurosporine | Cricetulus griseus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
XIAP inhibitors | peptide inhibitors | Cricetulus griseus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cricetulus griseus | apoptosis is a result of a complex network of signaling pathways initiating from both inside and outside the cell, culminating in the activation of caspases, cyteine aspartate proteases, that execute the final stages of cell death | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | - |
Cricetulus griseus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | apoptosis is a result of a complex network of signaling pathways initiating from both inside and outside the cell, culminating in the activation of caspases, cyteine aspartate proteases, that execute the final stages of cell death | Cricetulus griseus | ? | - |
? | |
N-carbobenzyloxy-DEVD-R110 + H2O | a fluorescent substrate | Cricetulus griseus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
caspase 3 | - |
Cricetulus griseus |