Literature summary for 3.4.22.52 extracted from

Fan, X.; Zhang, Q.; You, C.; Qian, Y.; Gao, J.; Liu, P.; Chen, H.; Song, H.; Chen, Y.; Chen, K.; Zhou, Y.
Proteolysis of the human DNA polymerase delta smallest subunit p12 by mu-calpain in calcium-triggered apoptotic HeLa cells (2014), PLoS ONE, 9, e93642.

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Inhibitors

Inhibitors	Comment	Organism	Structure
ALLN	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
p12 subunit of human DNA polymerase delta + H2O	Homo sapiens	the proteolysis of p12 by mu-calpain may be through a DNA polymerase delta4/PCNA complex. The p12/DNA polymerase delta is a target as a nuclear substrate of mu-calpain in calcium-triggered apoptosis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-LLY-7-amido-4-fluoromethylcoumarin + H2O	-	Homo sapiens	N-acetyl-LLY + 7-amino-4-fluoromethylcoumarin	-	?
p12 subunit of human DNA polymerase delta + H2O	the proteolysis of p12 by mu-calpain may be through a DNA polymerase delta4/PCNA complex. The p12/DNA polymerase delta is a target as a nuclear substrate of mu-calpain in calcium-triggered apoptosis	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
mu-calpain	-	Homo sapiens

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Release 2023.1 (January 2023)