Literature summary for 3.4.22.52 extracted from

Averna, M.; De Tullio, R.; Pedrazzi, M.; Bavestrello, M.; Pellegrini, M.; Salamino, F.; Pontremoli, S.; Melloni, E.
Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease (2015), PLoS ONE, 10, e0116738.

Search for more literature for 3.4.22.52

Inhibitors

Inhibitors	Comment	Organism	Structure
calpain inhibitor-1	-	Homo sapiens
calpastatin	the occurrence of a complex between heat shock protein 90 and calpain-1, in which the protease is still activable, can prevent the complete inhibition of the protease even in the presence of high calpastatin levels	Homo sapiens
heat shock protein 90	incubation of calpain-1 at a molar ratio of 1:1 with heat shock protein 90, at increasing Ca2+ concentrations, results in a significant decrease of calpain proteolytic activity at [Ca2+] up to 0.04 mM. At higher Ca2+ concentrations, the inhibiting effect of heat shock protein 90 is no more detectable	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	dependent on, 100% activity at concentrations higher than 0.04 mM	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
80000	-	x * 80000, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 80000, SDS-PAGE	Homo sapiens

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Release 2023.1 (January 2023)