Literature summary for 3.4.22.52 extracted from

Prangsaengtong, O.; Senda, K.; Doki, Y.; Park, J.Y.; Jo, M.; Sakurai, H.; Shibahara, N.; Saiki, I.; Koizumi, K.
Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation (2012), Hum. Cell, 25, 36-44.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphatic endothelial cell	-	Homo sapiens	-
lymphatic microvascular dermal-derived endothelial cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
calpain 1	-	Homo sapiens
mu-calpain	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	the knockdown of calpain 1 increases cell adhesion (by 36% after 30 min), enhances migration (by 46% after 12 h), and stabilizes late-stage cord formation on Matrigel by increasing cord length compared to the control human lymphatic microvascular dermal-derived endothelial cells	Homo sapiens
metabolism	calpain 1 is involved in the degradation of endothelial nitric oxide synthase and heat shock protein 90 and the phosphorylation of endothelial nitric oxide synthase	Homo sapiens

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Release 2023.1 (January 2023)